Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

• Radiotherapy affects immune populations in the TME, including MDSCs. Conventional fractionated radiation schedules are associated with MDSC recruitment. Radiotherapy, inflammation and hypoxia play a role function Both MDSC-intrinsic -extrinsic STING signaling able to alter behavior. Future studies should focus on elucidating potential of cGAS function. Myeloid derived suppressor cells (MDSCs) highly heterogeneous population immature immunosuppressive functions that recruited tumor microenvironment (TME). MDSCs promote growth progression by inhibiting effector cell proliferation affected both novel anti-cancer therapies targeting system anti-tumor immunity, as well conventional treatments such radiotherapy. Following radiotherapy, cytoplasmic double stranded DNA stimulates cyclic GMP-AMP synthase (cGAS)/stimulator interferon genes (STING) pathway, resulting type I production. Effectiveness radiotherapy cGAS/STING closely intertwined: activation is key generate systemic immunity after irradiation. This review focuses how and/or impact recruitment, expansion The influence ablative treatment schedules, inflammatory response following discussed modulators.